1) Recent Major Texts, Guidelines, Reviews, Papers and Editorials in support of Sublingual Immunotherapy.
1. Morogna, M. Preventitive effects of sublingual immunotherapy in childhood: An open randomized controlled study. Annals of Allergy, Asthma, and Immunotherapy. 2008; 101: 206-211.
2. Larenas-Linnemann, D. Sublingual immunotherapy: Dosing in relation to clinical and immunological efficacy. Allergy and Asthma Proceedings. 2008; 29(2):130-138.
3. Canonica, W., Passalacqua, G. Is Sublingual Immunotherapy the Final Answer? Implications for the Allergist. WAO Journal. April 2008: 70-72.
4. Bousquet, J., Khaltaev, N., Cruz, A., Denburg, J., Fokkens, J., Togias, T., et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 Update (in collaboration with the World Health Organization, GA2 LEN* and AllerGen**). Allergy. 2008; 63(86): 8-160.
5. Penagos, M., Passalacqua, G., Compalati, E., Baena-Cagnani, C., Orozco, S., Pedroza, A., et al. Metaanalysis of the Efficacy of Sublingual Immunotherapy in the Treatment of Allergic Asthma in Pediatric Patients, 3 to 18 Years of Age. CHEST. 2008; 133: 599-609.
6. Cox, L. Sublingual Immunotherapy in Pediatric Allergic Rhinitis and Asthma: Efficacy, Safety, and Practical Considerations. Pediatric Allergy and Immunology. 2007; 7: 410-420.
7. Didier, A., et al. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. American Academy of Allergy, Asthma & Immunology. October 2007: 1-8.
8. Pondrom, S. Sublingual Immunotherapy (SLIT) Quality of Life Outcomes. COSM 2007: American Rhinologic Society. 2007; 2(8): 24-25.
9. Cox, L. Sublingual immunotherapy, part 2: Safety and practical considerations. The Journal of Respiratory Disease. June 2007; 6: 237-243.
10. Tahamiler, R. Gkioukixel, S., Canakcioglu, S. Long-Term Efficacy of Sublingual Immunotherapy in Patients With Perennial Rhinitis. The Laryngoscope. 2007; 117:965-969.
11. Bachert, C., Vestenbaek, U., Christensen, J., Griffiths, U.K., Poulsen, P.B. Cost-effectiveness of grass allergen tablet (Grazax©) for the prevention of seasonal grass pollen induced rhinoconjunctivitis – a Northern European perspective. Clinical and Experimental Allergy. 2007; 37: 772-779.
12. Pham-Thi, N, et al. Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures. Pediatric Allergy and Immunology. 2007; 18: 47-57.
13. Bonds, R. S. et al. Allergic Disorders: When Should You Consider Immunotherapy? Consultant. 2007; 47( 4): 405-412.
14. Cox, L. Sublingual immunotherapy, part 1: Review of Clinical Efficacy. The Journal of Respiratory Diseases. 2007; 28(4): 162-168.
15. Nelson, H. S. Allergen immunotherapy: Where is it now? Journal of Allergy and Clinical Immunology. 2007; 119( 4): 769-779.
16. Durham, S. Tradition and innovation: Finding the right balance. Journal of Allergy and Clinical Immunology. 2007; 119( l4): 792-795.
17. Pajno, G. Sublingual immunotherapy: The optimism and the issues. Journal of Allergy and Clinical Immunology. 2007; 119( 4): 796-801.
18. Nelson, H. S. Advances in upper airway diseases and allergen immunotherapy. Journal of Allergy and Clinical Immunology. 2007; 119(4): 872-880.
19. Passalacqua, G . et al. Allergic Rhinitis and its Impact on Asthma update: Allergen immunotherapy. Journal of Allergy and Clinical Immunology. 2007; 119(4): 881-891.
20. Leatherman, B. et al. Sublingual Immunotherapy: Past, present, paradigm for the future? A review of the literature. Otolaryngology-Head and Neck Surgery. 2007; 136: S1-S20.
21. Marogna, M. et al. Effects of sublingual immunotherapy for multiple or single allergens in polysensitized patients. Annals of Allergy, Asthma & Immunology. 2007; 98: 274-280.
22. Finegold, I. Allergen immunotherapy; Present and future. Asthma and Allergy Proceedings. 2007; 28(1): 44-49.
23. Bellanti, J., Settipane, R. Sublingual immunotherapy: A procedure whose time has come? Asthma and Allergy Proceedings. 2007; 28(1), pages 1-2, January-February 2007.
24. Marogna M. et al . Long-Lasting Effects of Sublingual Immunotherapy for House Dust Mites in Allergic Rhinitis with Bronchial Hyperreactivity: A Long-Term (13-Year) Retrospective Study in Real Life. International Archives of Allergy & Immunology. 2006; 142(1): 70-78.
25. Passalacqua G., Canonica, G.W. Sublingual immunotherapy: update 2006. Current Opinion in Allergy and Clinical Immunology. 2006; 6: 449-454.
26. Werner-Klein, M. Sublingual immunotherapy of allergic diseases. Expert Opinion in.Drug Delivery. 2006; 3(5): 599-612.
27. Calamita, Z., Saconato, H., Pela, A.B., Atallah, A.N. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006; 61(10): 1162-72.
28. Berto, P. et al. Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: the Sublingual Immunotherapy Pollen Allergy Italy (SPAI) study. Annals of Allergy, Asthma and Immunology. 2006; 97: 615-621.
29. Passalacqua, G., et al. New Insights in Sublingual Immunotherapy. Current Allergy and Asthma Reports. 2006; 6: 407-412.
30. McEldowney, S. J. et al. Pollen Immunotherapy: Selection, Prevention, and Future Directions. Current Allergy and Asthma Reports. 2006; 4: 420-426.
31. Bousquet, J. Sublingual Immunotherapy: Validated! Allergy. 2006; 61( S81): 5.
32. Burastero, S. E. Sublingual immunotherapy for allergic rhinitis: an update. Current Opinion in Otolaryngology & Head and Neck Surgery. 2006; 14: 197-201.
33. Didier, A. Future developments in sublingual immunotherapy. Allergy. 2006; 61(Suppl. 81): 29-31.
34. Malling, H-J. “ublingual immunotherapy: efficacy – methodology and outcome of clinical trials. Allergy. 2006; 61(Suppl. 81): 24-28.
35. Moingeon, P. Sublingual immunotherapy: from biological extracts to recombinant allergens. Allergy. 2006; 61(Suppl. 81): 15-19.
36. Passalacqua, G. et al. Randomized double-blind controlled study with sublingual carbamylated allergoid immunotherapy in mild rhinitis due to mites. Allergy. 2006; 61: 849-854.
37. Canonica, G.W., Passalacqua G. Sublingual Immunotherapy in the Treatment of Adult Allergic Rhinitis Patients. Allergy. 2006; 61: 20.
38. Pham-Thi, N. et al. Sublingual immunotherapy in the treatment of children. Allergy. 2006; 61 (Suppl. 81): 7-10.
39. Ortolani, C. et al. Practice parameters for sublingual immunotherapy. Monaldi Archives for Chest Disease. 2006; 65(1): 44-6.
40. Guerra, L. et al. Randomized open comparison of the safety of SLIT in a no-updosing and traditional updosing schedule in patients with Parietaria allergy. Allergologia et immunopathologia. 2006; 34(02): 82-83.
41. Mascarell, L., et al. Novel Ways for Immune Intervention in Immunotherapy: Mucosal Allergy Vaccines. Immunology and Allergy Clinics of North America. 2006; 26: 283-306.
42. Cox, L. et al. Sublingual immunotherapy: A comprehensive review. Journal of Allergy and Clinical Immunology. 2006; 117(5): 1021-1035.
43. Nelson, H. Advances in upper airway diseases and allergen immunotherapy. Journal of Allergy and Clinical Immunology. 2006; 117(5): 1047-1053.
44. Durham, S. et al. Sublingual immunotherapy with once-daily grass allergen tablets: A randomized controlled trial in seasonal allergic rhinoconjunctivitis. Journal of Allergy and Clinical Immunology. 2006; 117(4): 802-809.
45. Passalacqua, G. e. al. Non-Injection Routes for Allergen Immunotherapy: Focus on Sublingual Immunotherapy. Inflammation & Allergy – Drug Targets. 2006; 5: 43-51.
46. Passalacqua, G. et al. Quantitative assessment of the compliance with once-daily sublingual immunotherapy regimen in real life (EASY Project: Evaluation of A novel SLIT formulation during a Year” ). Journal of Allergy and Clinical Immunology. 2006; 117(4).
47. Potter, P, Update on sublingual immunotherapy. Annals of Allergy, Asthma and Immunology. 2006; 96(Suppl 1): S22-S25.
48. Bieber, T. Allergen-specific sublingual immunotherapy: less mystic, more scientific. Allergy. 2006; 61: 149-150.
49. Dahl R. et al. Specific immunotherapy with SQ standardized grass allergen tablets in asthmatics with rhinoconjunctivitis. Allergy. 2006; 61: 185-190.
50. Cingi, C. et al. Efficacy of long-term sublingual-oral immunotherapy in allergic rhinitis. ACTA Otorhinolaryngol Ital. 2005; 25: 214-219.
51. Marogna, M. et al. Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study. Journal of Allergy and Clinical Immunology. 2005; 115(6): 1184-1188.
52. Gidaro, G.B., et al. The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clinical & Experimental Allergy. 2005; 35: 565-571.
53. Pajno, G. Allergen immunotherapy in early childhood: between Scylla and Charbydis! Clinical & Experimental Allergy. 2005; 35: 551-553.
54. Courtney, A.U, et al. Childhood Asthma: Treatment Update. American Family Physician. 2005; 71(10): 1959-1968.
55. Parks, K. Advances in Immunotherapy: Current Considerations and Beyond. The Allergy and Immunology Report. 2005; 1(2).
56. Bousquet, J. Sublingual immunotherapy: from proven prevention to putative rapid relief of allergic symptoms. Allergy. 2005; 60: 1-3.
57. Lambrecht, B.N. Dendritic cells in the pathogenesis of asthma. Clinical and Experimental Allergy. 2004; 4: 123-128
58. Nelson, H. Advances in upper airway diseases and allergen immunotherapy. Journal of Allergy and Clinical Immunology. 2004; 113(4):635-42.
59. Passalacqua, G. et al. Efficacy and safety of sublingual immunotherapy. Annals of Allergy, Asthma, and Immunology. 2004; 93(1): 3-12.
60. Portnoy J. Allergen Immunotherapy in the Prevention of Asthma. Current Opinion Allergy Clinical Immunology. 2004; 4(2): 131-136.
61. Passalacqua, G, Canonica, G.W. Sublingual or injection immunotherapy: the final answer? Allergy. 2004; 59: 37-38.
62. Malling, H.J. Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results. Current Opinion in Allergy and Clinical Immunology. 2004; 4: 539-542.
63. Mosages, R. The role of hyposensitization: do we need to start rethinking? Clinical Opinion in Allergy and Clinical Immunology. 2004; 4: 155-157.
64. Norman, P. S. Immunotherapy: 1999-2004. Journal of Allergy and Clinical Immunology. 2004; 113(6): 1013-1023.
65. Passalacqua G., Lombardi C., Canonica G.W. Sublingual Immunotherapy: An Update. Current Opinion in Allergy and Clinical Immunology. 2004; 4(1).
66. Markert, U.R. and Elsner P. Local Immunotherapy in Allergy. Chemical Immunology and Allergy. (lead chapter by D. Morris, et al). 2003; Vol. 82, Karger, Basel, Switzerland.
67. Wilson, D.R., Torres, L.M., Durham, S.R. Sublingual immunotherapy for allergic rhinitis. (Cochrane Review), The Cochrane Library, Issue 2. 2003.
68. Canonica, G. W. and Passalacqua, G. Non-injection routes for immunotherapy. Journal of Allergy and Clinical Immunology. 2003; 111(3): 437-448.
69. Nelson, H. S. Advances in upper airway diseases and allergen immunotherapy. Journal of Allergy and Clinical Immunology. 2003; 111(3): S793-798.
70. Di Rienzo, V., Canonica, G.W., and Passalacqua G. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10 year prospective study. Clinical and Experimental Allergy. 2003; 33: 206-210.
71. Bielory L., Heimall. Review of complementary and alternative medicine in treatment of ocular allergies. Current Opinion in Allergy and Clinical Immunology. 2003; 3: 395-399.
72. Passalacqua, G, Baena-Cagnani, C., Berardi, M., Canonica, G.W. Oral and sublingual immunotherapy in pediatric patients. Current Opinion in Allergy and Clinical Immunology. 2003; 3(2): 139-145.
73. Li, J. et al. Allergen immunotherapy: a practice parameter. Journal of Allergy and Clinical Immunology. 2003; 90: 27.
74. Kagi M.K., Wuthrich, B. Different methods of local allergen-specific immunotherapy. Allergy. 2002; 57: 379-388.
75. Reiber, M.E. Sublingual Administration of Allergen Desensitization. Tennessee Medicine. 2002: 465-467.
76. Douglass, J., O’Hehir, R. Specific allergen immunotherapy: time for alternatives? Clinical and Experimental Allergy. 2002; 32: 1-3.
77. Bousquet, J. The new ARIA guidelines: putting science into practice, Clinical and Experimental Allergy Review. 2002; 2:38-43.
78. Volpe, A. Della, et al. Sublingual Allergen-Specific Immunotherapy in Allergic Rhinitis and Related Pathologies: Efficacy in a Pediatric Population. International Journal of Immunopathology and Pharmacology. 2002; 15(1): 35-40.
79. Malling, H. Is Sublingual Immunotherapy Clinically Effective? Current Opinion Allergy and Clinical Immunology. 2002; 2(6): 523-532.
80. Allergic Rhinitis and its impact on Asthma (ARIA) Workshop Report. Journal of Allergy and Clinical Immunology. 2001; 108(5).
81. Bousquet, J. ARIA Workshop Group Guidelines. Journal of Allergy and Clinical Immunology. 2001: S242-S245.
82. Passalacqua G., Canonica, G.W. Allergen-Specific Sublingual Immunotherapy for Respiratory Allergy. BioDrugs. 2001; 15(8): 509-519.
83. Morris, D.L. Current use of sublingual-swallow immunotherapy. Current Opinion in Otolaryngology & Head and Neck Surgery. 2001; 9(3):179-180.
84. Marogna, M. et al. Clinical Practice Improvement Program for Immunotherapy of Respiratory Allergic Diseases. International Journal of Immunopathology and Pharmacology. 2001;14(2): 93-101.
85. Theodorpoulos, D., Lockey, R. Allergen Immunotherapy: Guidelines, Update and Recommendations of the World Health Organization. Allergy and Asthma Proceedings. Pg. 2000; 21(3): 159-66.
86. Frew, A. et al. Sublingual Immunotherapy. Journal of Allergy Clinical Immunology. 2001: 441-444.
87. Brown, J.L., Frew, A..J. The efficacy of oromucosal immunotherapy in respiratory allergy. Clinical & Experimental Allergy. 2001; 21(1): 8-10.
88. Rakoski, J., Wessner, D. A Short Assessment of Sublingual Immunotherapy. International Archives of Allergy and Immunology. 2001; 126: 185-187.
89. Pineda-Algorta, J. et al. Study of the efficacy of sublingual immunotherapy in patients with grass pollen sensitization: Mini Symposium 3 Sublingual Immunotherapy. Allergy. 2000; 63(55): 24.
90. Ano-Garcia, M. et al. Efficacy and safety of sublingual immunotherapy in patients with sensitization to Dermtophagoides pteronyssinus: Mini Symposium 3 Sublingual Immunotherapy. Allergy. 2000; 55(63): 24.
91. Khinchi, M.S. et al. Clinical efficacy of sublingual-swallow and subcutaneous immunotherapy in patients with allergic rhinoconjunctivitis due to birch pollen: Mini Symposium 3 Sublingual Immunotherapy. Allergy. 2000; 63(55): 24.
92. Donato, R.M. Patients with allergic rhinitis from Argentine treated with SLIT (sublingual immunotherapy) a non-injective route – Abstract presented October 2000 IACAI Conf.
93. Malling, H.J. Allergen-specific immunotherapy. Present state and directions for the future. Allergy. 1999; 54: 30-33.
94. Passalacqua, G. et al. Oral and Sublingual Immunotherapy: General Aspects and Critical Considerations. WMW Themenheft: Hyposensibilsierung. 1999: 433-437.
95. Donahue, J.G. et al. Utilization and cost of immunotherapy for allergic asthma and rhinitis. Annals of Allergy, Asthma and Immunology. 1999; 82: 339-347.
96. Bousquet J., Lockey R., Malling H.J. Allergen immunotherapy: therapeutic vaccines for allergic diseases. World Health Organization Position Paper Allergy. 1998; 53(44): 1-29.
97. Malling, H.J. Sublingual Immunotherapy. Clinical Experimental Allergy. 1996; 26: 1228-1231.
98. Passalacqua G., G.W. Canonica. Alternative routes for allergen-specific immunotherapy. Journal of Investigational Allergology and Clinical Immunology. 1996; 6(2): 81-87.
99. Creticos, P.S. A review of oral specific immunotherapy: Expressions on allergen specific immunotherapy. Stallergenes S.A. 1995: 1. (US Based DBPC Study)